曾蔼霖，李惠如，胡小艳， 杨敏芝，母梅力，陈 姚，刘建国,2，吴明松,2

    (1.遵义医科大学 口腔医学院，贵州 遵义 563099；2.遵义医科大学 贵州省普通高等学校口腔疾病研究特色重点实验室，贵州 遵义 563099)

    Fluorine is a necessary trace element of organisms,and is good for health so that the fluoride is routinely added in toothpaste and public water in many countries.Nevertheless,excessive fluoride may bring about damage to animals.Its hazard is mainly in violation of teeth and bones,causing dental fluorosis and bone fluorosis,extensive distribution,and the number of patients[1].fluorosis is a kind of endemic disease throughout the world,and the dental and skeletal fluorosis are common diseases in clinic.Hence it is a controversial issue of the fluoridation.

    Currently,tumorigenesis of excessive fluoride is concerned by more and more scientists who propose that fluoride interferes with the normal biology or/and genetics of the body,and further suppose that fluoride is linked to the development of osteosarcoma[2].However,others believe that there is no evidence that higher levels of fluoride lead to a greater risk of either osteosarcoma or Ewing sarcoma[3].It is worth noting that most of the debates focused on the bone tumor.So we report here on a kind of soft tissue tumor from a rat with dental fluorosis in order to provide a case to the debate. ......