妊娠期糖尿病阴道微生态研究(1)
摘要：目的 了解妊娠期糖尿病(GDM)孕妇阴道微生态情况，为妊娠期糖尿病孕妇常见阴道炎进行预防及治疗提供依据。方法 对2017年8月—2018 年07月间在本院行规范产前检查的孕24-28周的孕妇进行糖尿病筛查，如符合妊娠期糖尿病的孕妇同时进行阴道分泌物常规检查作为研究组，同期健康孕妇为对照组，对于妊娠期糖尿病孕妇进行健康教育指导及治療，4周后两组病人均进行复查(血糖及阴道分泌物常规)。 结果 妊娠期糖尿病孕妇pH值较对照组无差异，阴道乳杆菌较对照组少，霉菌检查率和细菌阴道病检出率均较对照组多，差异有统计学意义(P<0.05)。结论 妊娠期糖尿病孕妇阴道微生态失衡，增加了阴道感染性疾病的发生率;提示临床应该重视妊娠期糖尿病孕妇阴道微生态情况，同时指导孕妇控制血糖水平，以改善阴道微生态环境，减少妊娠不良结局的发生。
关键词：妊娠期糖尿病;阴道微生态;感染;血糖控制
【中图分类号】R271.1 【文献标识码】A 【文章编号】2107-2306(2019)04-047-03
Vaginal microecology study in pregnant women with gestational diabetes
First People's Hospital of Fangchenggang City， Guangxi Province， China，Ye Xiujuan， Huang Jianying， Li Tiejun， Zhong Qijuan，Fangchenggang， Guangxi 538021， China
Objective Understanding the vaginal micro-ecology of pregnant women with gestational diabetes mellitus (GDM) ，and provide evidence for the prevention and treatment of common vaginitis in pregnant women with gestational diabetes.
Methods Diabetes screening was performed on 24-28 weeks pregnantcy women who were scheduled for Standardize prenatal care in our hospital from August 2017 to July in 2018.
Routine vaginal discharge examination was performed as a research group for who has gestational diabetes.
Healthy pregnant women served as the control group in the same period.
For pregnant women with gestational diabetes， they were given health education guidance and treatment. both groups of patients were reviewed (blood sugar and vaginal secretions routine) after 4 weeks.
Conclusion The vaginal micro-ecological imbalance in pregnant women with gestational diabetes increases the incidence of vaginal infectious diseases.
It suggests that the vaginal micro-ecology of pregnant women with gestational diabetes should be emphasized， and should be instructed to control blood sugar levels to improve the vaginal micro-ecological environment and reduce pregnancy malnutrition.
[Key words] Gestational diabetes; vaginal micro-ecology; infection; blood sugar control.
妊娠期糖尿病是指孕妇在怀孕后首次被确诊为糖尿病的患者。近年来，由于饮食的变化等原因。中国妊娠期糖尿病发生率逐年上升[1]。妊娠期糖尿病会导致胎儿出现先天性畸形、早产、低体重儿、巨大儿、孕妇感染等，是引起围产儿死亡的主要原因之一。妊娠期糖尿病患者伴生殖道感染是妊娠期糖尿病患者常见的并发症之一，对孕妇和胎儿的预后均可造成不良的影响[2]，本文旨在通过对妊娠期糖尿病孕妇阴道微生态研究，为妊娠期糖尿病孕妇常见阴道炎进行预防及治疗提供依据。
1 资料与方法
1.1 一般资料 对2017年8月—2018年07月间在本院规范产前检查的孕妇于孕24～28周进行糖尿病筛查，如符合妊娠期糖尿病的孕妇作为研究对象，入组标准：(1)患者符合妊娠期糖尿病的诊断标准;(2) 均自愿参加本次研究，签署知情同意书; 排除标准：(1) 患者有心肝肾等重大疾病;(2) 患者孕前已经确诊为糖尿病;(3)患者不愿意参加本次研究。对入组病例进行阴道分泌物常规检查，对研究组孕妇进行健康教育和相关治疗，4周后复查血糖和阴道分泌物。研究组孕妇年龄，20.7-40.6岁之间，平均年龄为(29.6±10.5)岁，孕周在24-31.7周之间，平均孕周为(29.5±1.6)周;同期健康正常孕妇24-28周的设为对照组。平均年龄在20.3-37.5岁年龄(27.1±11.2)岁，孕周在24-31.5周之间，平均孕周为(28.5.8±1.5)周，对, http://www.100md.com(叶秀娟 黄健英 李铁军 钟其娟)
关键词：妊娠期糖尿病;阴道微生态;感染;血糖控制
【中图分类号】R271.1 【文献标识码】A 【文章编号】2107-2306(2019)04-047-03
Vaginal microecology study in pregnant women with gestational diabetes
First People's Hospital of Fangchenggang City， Guangxi Province， China，Ye Xiujuan， Huang Jianying， Li Tiejun， Zhong Qijuan，Fangchenggang， Guangxi 538021， China
Objective Understanding the vaginal micro-ecology of pregnant women with gestational diabetes mellitus (GDM) ，and provide evidence for the prevention and treatment of common vaginitis in pregnant women with gestational diabetes.
Methods Diabetes screening was performed on 24-28 weeks pregnantcy women who were scheduled for Standardize prenatal care in our hospital from August 2017 to July in 2018.
Routine vaginal discharge examination was performed as a research group for who has gestational diabetes.
Healthy pregnant women served as the control group in the same period.
For pregnant women with gestational diabetes， they were given health education guidance and treatment. both groups of patients were reviewed (blood sugar and vaginal secretions routine) after 4 weeks.
Conclusion The vaginal micro-ecological imbalance in pregnant women with gestational diabetes increases the incidence of vaginal infectious diseases.
It suggests that the vaginal micro-ecology of pregnant women with gestational diabetes should be emphasized， and should be instructed to control blood sugar levels to improve the vaginal micro-ecological environment and reduce pregnancy malnutrition.
[Key words] Gestational diabetes; vaginal micro-ecology; infection; blood sugar control.
妊娠期糖尿病是指孕妇在怀孕后首次被确诊为糖尿病的患者。近年来，由于饮食的变化等原因。中国妊娠期糖尿病发生率逐年上升[1]。妊娠期糖尿病会导致胎儿出现先天性畸形、早产、低体重儿、巨大儿、孕妇感染等，是引起围产儿死亡的主要原因之一。妊娠期糖尿病患者伴生殖道感染是妊娠期糖尿病患者常见的并发症之一，对孕妇和胎儿的预后均可造成不良的影响[2]，本文旨在通过对妊娠期糖尿病孕妇阴道微生态研究，为妊娠期糖尿病孕妇常见阴道炎进行预防及治疗提供依据。
1 资料与方法
1.1 一般资料 对2017年8月—2018年07月间在本院规范产前检查的孕妇于孕24～28周进行糖尿病筛查，如符合妊娠期糖尿病的孕妇作为研究对象，入组标准：(1)患者符合妊娠期糖尿病的诊断标准;(2) 均自愿参加本次研究，签署知情同意书; 排除标准：(1) 患者有心肝肾等重大疾病;(2) 患者孕前已经确诊为糖尿病;(3)患者不愿意参加本次研究。对入组病例进行阴道分泌物常规检查，对研究组孕妇进行健康教育和相关治疗，4周后复查血糖和阴道分泌物。研究组孕妇年龄，20.7-40.6岁之间，平均年龄为(29.6±10.5)岁，孕周在24-31.7周之间，平均孕周为(29.5±1.6)周;同期健康正常孕妇24-28周的设为对照组。平均年龄在20.3-37.5岁年龄(27.1±11.2)岁，孕周在24-31.5周之间，平均孕周为(28.5.8±1.5)周，对, http://www.100md.com(叶秀娟 黄健英 李铁军 钟其娟)