摘要：目的：比较丙戊酸钠合并改良电休克与合并舍曲林治疗双相抑郁的疗效与安全性。方法：将43例双相抑郁患者随机分成两组，分别接受丙戊酸钠合并改良电休克治疗(Modified electric convulsive treatment，MECT)、丙戊酸钠合并舍曲林治疗，用17项汉密尔顿抑郁量表(17 items of Hamilton rating scale for depression，HAMD-17)、韦氏成人记忆量表(Wechsler memory scale，WMS)、治疗中需处理的不良反应症状量表(Treatment emergent symptoms scale，TESS)评估疗效及副反应情况。结果：①MECT组与舍曲林组HAMD评分较治疗前均明显减低，MECT组有效率为86.4%，舍曲林组有效率为76.2%，二组间有效率有统计学差异。②MECT组前四周WMS评分减低，与治疗前及舍曲林组间均有统计学差异，第8周末时研究MECT组WMS评分与治疗前及舍曲林组间无明显差异，两组间副反应出现率无明显差异。结论：改良电休克合并丙戊酸钠治疗双相抑郁安全、有效。

    关键词：改良电休克；丙戊酸钠；双向抑郁

    A random controlled study of combination of sodium Valproate and modified electric convulsive treatment for bipolar depression

    【Abstract】 Objective：To compare the effect and adverse events of sodium valproate with modified electric convulsive treatment(MECT)and sodium valproate with sertraline in the treatment of bipolar depression. Methods：Forty three inpatients with bipolar depression were entered into the study by a random ......