质谱技术在抗体药物分析中的应用(2)
参考文献:
[1]王兰,朱磊,徐刚领,等.单克隆抗体类生物治疗药物研究进展[J].中国药学杂志,2014,49(23):2058-2064.
[2]李壮林,姚雪静. 单克隆抗体药物研究进展[J].药物生物技术,2014,21(5):456-461.
[3]Austin CD,Wen X,Gazzard L,et al. Oxidizing potential of endosomes and lyosomes limits intracellular cleavage of disulfidebased antibody-drug conjugates[J]. Proc Natl Acad Sci,2005,102(50):17987-17992.
[4]Kontenrmann,R. Dual targeting strategies with bispecific antibodies[J]. Mabs,2012,4(2):182-197.
[5]Vestal M L,Juhasz P. Delayed extraction matrix-assisted laser desorption time-of-flight mass spectrometry.[J].Rapid Commun Mass Spectrom,1995,9:1044-1050
[6]Tisato F,Bolzati C,Porchia M.Contribution of electrospray mass spectrometry for characterization,design,and development of nitride technetium and rhenium heterocomplexes as potential radiopharmaceuticals[J]. Mass Spectrometry Reviews,Published Online,2004,23(5):309-332.
[7]李萌,于傳飞,王馨,等. 相对分子质量测定作为单抗药物常规放行分析方法的可行性商榷[J]. 药物分析杂志,2015,12:2076-2082.
[8]Zhu L,Guo Q,Guo H,et al.Versatile characterization of glycosylation modification in CTLA4-Ig fusion proteins by liquid chromatography-mass spectrometry. [J]. MAbs. 2014;6(6):1474-1485.
[9]于传飞,李萌,郭玮,等. 一种抗体药物偶联物中药物抗体偶联比的测定[J]. 药学学报,2014,03:363-367.
[10]Wakankar A Chen Y,Gokarn Y,et al. Analytical methods for physicochemical characterization of antibody drug conjugates. [J]. MAbs. 2011;3(2):161-172.
[11]Duan X T,Dai L P,Chen S C,et al. Nano-scale liquid chromatography/mass spectrometry and on-the-fly orthogonal array optimization for quantification of therapeutic monoclonal antibodies and the application in preclinical analysis. [J]. J Chromatogr A,2012,1251(17):63-73.
[12]Stackhouse N,Miller AK,Gadgil HS. A high-throughput UPLC method for the characterization of chemical modifications in monoclonal antibody molecules. [J].J Pharm Sci. 2011;100(12):5115-5125.
作者简介:高燕波(1990~),女,研究方向为抗体药物研发。正在攻读上海交通大学生物工程专业硕士;Email:gaoyanbo_1990@163.com, 百拇医药
[1]王兰,朱磊,徐刚领,等.单克隆抗体类生物治疗药物研究进展[J].中国药学杂志,2014,49(23):2058-2064.
[2]李壮林,姚雪静. 单克隆抗体药物研究进展[J].药物生物技术,2014,21(5):456-461.
[3]Austin CD,Wen X,Gazzard L,et al. Oxidizing potential of endosomes and lyosomes limits intracellular cleavage of disulfidebased antibody-drug conjugates[J]. Proc Natl Acad Sci,2005,102(50):17987-17992.
[4]Kontenrmann,R. Dual targeting strategies with bispecific antibodies[J]. Mabs,2012,4(2):182-197.
[5]Vestal M L,Juhasz P. Delayed extraction matrix-assisted laser desorption time-of-flight mass spectrometry.[J].Rapid Commun Mass Spectrom,1995,9:1044-1050
[6]Tisato F,Bolzati C,Porchia M.Contribution of electrospray mass spectrometry for characterization,design,and development of nitride technetium and rhenium heterocomplexes as potential radiopharmaceuticals[J]. Mass Spectrometry Reviews,Published Online,2004,23(5):309-332.
[7]李萌,于傳飞,王馨,等. 相对分子质量测定作为单抗药物常规放行分析方法的可行性商榷[J]. 药物分析杂志,2015,12:2076-2082.
[8]Zhu L,Guo Q,Guo H,et al.Versatile characterization of glycosylation modification in CTLA4-Ig fusion proteins by liquid chromatography-mass spectrometry. [J]. MAbs. 2014;6(6):1474-1485.
[9]于传飞,李萌,郭玮,等. 一种抗体药物偶联物中药物抗体偶联比的测定[J]. 药学学报,2014,03:363-367.
[10]Wakankar A Chen Y,Gokarn Y,et al. Analytical methods for physicochemical characterization of antibody drug conjugates. [J]. MAbs. 2011;3(2):161-172.
[11]Duan X T,Dai L P,Chen S C,et al. Nano-scale liquid chromatography/mass spectrometry and on-the-fly orthogonal array optimization for quantification of therapeutic monoclonal antibodies and the application in preclinical analysis. [J]. J Chromatogr A,2012,1251(17):63-73.
[12]Stackhouse N,Miller AK,Gadgil HS. A high-throughput UPLC method for the characterization of chemical modifications in monoclonal antibody molecules. [J].J Pharm Sci. 2011;100(12):5115-5125.
作者简介:高燕波(1990~),女,研究方向为抗体药物研发。正在攻读上海交通大学生物工程专业硕士;Email:gaoyanbo_1990@163.com, 百拇医药