《实验医学杂志》.2005年.第1期

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• Contrasting models of promiscuous gene expression by thymic epithelium
• Loss of C/EBP cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage
• Restricted MHC–peptide repertoire predisposes to autoimmunity
• Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice
• Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn
• v3-dependent cross-presentation of matrix metalloproteinase–2 by melanoma cells gives rise to a new tumor antigen
• A multipotent precursor in the thymus maps to the branching point of the T versus B lineage decision
• Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels
• Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function
• Conversion of CD4+ CD25– cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus
• Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced risk
• Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin
• Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block
• An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II–restricted T cells in the absence of CD4
• NKT cells promote antibody-induced joint inflammation by suppressing transforming growth factor 1 production
• Positive selection of the peripheral B cell repertoire in gut-associated lymphoid tissues
• Do developing B cells need antigen
• Role of 2-integrins for homing and neovascularization capacity of endothelial progenitor cells
• Hypoxia-induced neutrophil survival is mediated by HIF-1–dependent NF-B activity
• Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines
• Identification and characterization of an endogenous chemotactic ligand specific for FPRL2
• Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness
• TACI and BAFF-R mediate isotype switching in B cells
• The Plasmodium circumsporozoite protein is proteolytically processed during cell invasion
• Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling
• Inhibition of astroglial nuclear factor B reduces inflammation and improves functional recovery after spinal cord injury
• Plasmacytoid predendritic cells initiate psoriasis through interferon- production
• Many roads, one destination for T cell progenitors
• BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation
• Differential contributions of central and effector memory T cells to recall responses
• The timing of TCR expression critically influences T cell development and selection
• Dendritic cells star in Vancouver
• Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis
• Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27Kip1 degradation