《国际神经病学神经外科学杂志》.2006年.第9期

　

• Relating TCR-peptide-MHC affinity to immunogenicity for the design of tumor vaccines
• Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M
• The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1–/– mice
• Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation
• CD40 induces macrophage anti–Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosom
• Cholesterol precursors and facial clefting
• Adaptive human regulatory T cells: myth or reality?
• In This Issue
• PTEN inhibits IL-2 receptor–mediated expansion of CD4+ CD25+ Tregs
• Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycar
• Bone protection by estrens occurs through non–tissue-selective activation of the androgen receptor
• Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling
• Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans
• Role of IFN- in induction of Foxp3 and conversion of CD4+ CD25– T cells to CD4+ Tregs
• Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo
• Impaired clearance of apoptotic cardiocytes is linked to anti-SSA/Ro and -SSB/La antibodies in the pathogenesis of congenital heart block
• FcRIII engagement provides activating signals to NKT cells in antibody-induced joint inflammation
• The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity
• Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism
• Molecular basis for the modulation of native T-type Ca2+ channels in vivo by Ca2+ /calmodulin-dependent protein kinase II
• Myelin oligodendrocyte glycoprotein–specific T and B cells cooperate to induce a Devic-like disease in mice
• Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin
• Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis
• Endothelial cell–restricted disruption of FoxM1 impairs endothelial repair following LPS-induced vascular injury
• Deconstructing endothelial dysfunction: soluble guanylyl cyclase oxidation and the NO resistance syndrome
• You say estren, I say estrogen. Let’s call the whole replacement off!
• Connexin 43 mediates spread of Ca2+-dependent proinflammatory responses in lung capillaries
• Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels
• TRAIL receptor–mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality
• Supporting junior faculty in the academic system: time for a change?
• Pneumonia before antibiotics
• Medical marvels
• A mighty mouse: building a better model of multiple sclerosis
• Regeneration of the endothelium as a novel therapeutic strategy for acute lung injury
• Toll-like receptors and IFN-: partners in autoimmunity