《联合生物学》.2005年.第8期

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• Regulation of ubiquitin ligase dynamics by the nucleolus
• Support for the immortal strand hypothesis : neural stem cells partition DNA asymmetrically in vitro
• Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores
• AtRMR1 functions as a cargo receptor for protein trafficking to the protein storage vacuole
• Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A
• Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle
• A glue for heterochromatin maintenance : stable SUV39H1 binding to heterochromatin is reinforced by the SET domain
• The origin recognition core complex regulates dendrite and spine development in postmitotic neurons
• FAPP2 is involved in the transport of apical cargo in polarized MDCK cells
• Dendrite development : a surprising origin
• The epidermal barrier function is dependent on the serine protease CAP1/Prss8
• Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain
• Essential role of CIB1 in regulating PAK1 activation and cell migration
• The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex
• Mammalian WDR12 is a novel member of the Pes1–Bop1 complex and is required for ribosome biogenesis and cell proliferation
• Dynamic formation of RecA filaments at DNA double strand break repair centers in live cells
• A local mechanism mediates NAD-dependent protection of axon degeneration
• sdfsfasfasfIndependent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells
• PTP-1B is an essential positive regulator of platelet integrin signaling
• CEACAM engagement by human pathogens enhances cell adhesion and counteracts bacteria-induced detachment of epithelial cells
• Identification of FIP200 interaction with the TSC1–TSC2 complex and its role in regulation of cell size control
• The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila
• Regulatory mechanisms required for DE-cadherin function in cell migration and other types of adhesion
• A Rac switch regulates random versus directionally persistent cell migration
• Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells
• Assembly and trafficking of caveolar domains in the cell : caveolae as stable, cargo-triggered, vesicular transporters
• Elevated expression of MITF counteracts B-RAF–stimulated melanocyte and melanoma cell proliferation
• Process outgrowth in oligodendrocytes is mediated by CNP, a novel microtubule assembly myelin protein
• -Catenin controls cell sorting at the notochord–somite boundary independently of cadherin-mediated adhesion
• Interactions of WASp, myosin-I, and verprolin with Arp2/3 complex during actin patch assembly in fission yeast
• An AP-1/clathrin coat plays a novel and essential role in forming the Weibel-Palade bodies of endothelial cells
• Reaching out for signals : filopodia sense EGF and respond by directed retrograde transport of activated receptors
• An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway
• Transcytosis of NgCAM in epithelial cells reflects differential signal recognition on the endocytic and secretory pathways
• Rho GTPase regulation of exocytosis in yeast is independent of GTP hydrolysis and polarization of the exocyst complex
• An ECT2–centralspindlin complex regulates the localization and function of RhoA
• Cyclic AMP and calcium interplay as second messengers in melatonin-dependent regulation of Plasmodium falciparum cell cycle
• The Rho kinases I and II regulate different aspects of myosin II activity
• Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulin
• Maternal embryonic leucine zipper kinase(MELK) regulates multipotent neural progenitor proliferation
• The limited role of NH2-terminal c-Jun phosphorylation in neuronal apoptosis : Identification of the nuclear pore complex as a potential tar
• Viruses activate a genetically conserved cell death pathway in a unicellular organism