《细胞学杂志》.2003年.第3期

基础医学

• Spatial and temporal expression of heparan sulfate in mouse developmen
• Avidity enhancement of L-selectin bonds by flow : shear-promoted rotat
• Stressed cells dance on a bright stage
• Getting a handle on centrosomes
• The neutrophil as firefighter
• Breaking down barriers
• Math connects vascular network to the universe
• MicroRNAs make big splash in apoptosis
• Shared amyloid oligomer structure proves toxic
• Amyloid as a natural product
• Holey barrier : claudins and the regulation of brain endothelial perme
• Crm1 locks up replication factors
• Modeling network dynamics : the lac operon, a case study
• Inventories to insights
• Computational cell biology
• Spindle orientation in Saccharomyces cerevisiae depends on the transpo
• Turning RacGAP into a RhoGAP
• Computational imaging in cell biology
• Oscillatory nucleocytoplasmic shuttling of the general stress response
• Neurofilament heavy chain side arm phosphorylation regulates axonal tr
• -Adducin dissociates from F-actin and spectrin during platelet activat
• Androgen-stimulated DNA synthesis and cytoskeletal changes in fibrobla
• Neural cell adhesion molecule(NCAM) association with PKC?2 via ?I spe
• Size-selective loosening of the blood-brain barrier in claudin-5–defic
• Role of Drosophila Rab5 during endosomal trafficking at the synapse an
• A novel human protein of the maternal centriole is required for the fi
• deep-orange and carnation define distinct stages in late endosomal bio
• A model of missegregation
• Multimembrane fusion
• Two motors, one transmission
• Is Botryllus a natural killer?
• Anthrax toxin takes charge
• Urge to merge erects filopodia
• Bacterial aging
• Replicating dominos
• Hearts grow with the flow
• The intramitochondrial dynamin-related GTPase, Mgm1p, is a component o
• LIS1 at the microtubule plus end and its role in dynein-mediated nucle
• Dynactin polices two-way organelle traffic
• Poised to migrate
• Anthrax toxin rafts into cells
• Anthrax toxin triggers endocytosis of its receptor via a lipid raft–me
• Mechanism of filopodia initiation by reorganization of a dendritic net
• Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polari
• EPLIN regulates actin dynamics by cross-linking and stabilizing filame
• A biomimetic motility assay provides insight into the mechanism of act
• The ZO-1–associated Y-box factor ZONAB regulates epithelial cell proli
• Drosophila p120catenin plays a supporting role in cell adhesion but is
• Binding site for p120/-catenin is not required for Drosophila E-cadher
• Hierarchy of protein assembly at the vertex ring domain for yeast vacu
• The budding yeast Ipl1/Aurora protein kinase regulates mitotic spindle
• The role of the lissencephaly protein Pac1 during nuclear migration in
• Cellular levels of p120 catenin function as a set point for cadherin e
• ROCK-generated contractility regulates breast epithelial cell differen
• A core function for p120-catenin in cadherin turnover
• MT1-MMP–dependent, apoptotic remodeling of unmineralized cartilage : a
• Processing by proprotein convertases is required for glypican-3 modula
• Defining BMP functions in the hair follicle by conditional ablation of
• Latching onto fibrinogen
• A kinase that activates by occupancy
• Passing along polarity
• Calcium mobilization from mitochondria in synaptic transmitter release
• Traffic control : p120-catenin acts as a gatekeeper to control the fat
• Damage first; infect later
• How to renew a stem cell
• Cloning of the first sn1-DAG lipases points to the spatial and tempora
• Morphologically distinct microtubule ends in the mitotic centrosome of
• Myosin V motor proteins : marching stepwise towards a mechanism
• SUMO-2/3 regulates topoisomerase II in mitosis
• Mice with defects in HB-EGF ectodomain shedding show severe developmen
• A function for the mitochondrial chaperonin Hsp60 in the structure and
• Ca2+ influx–independent synaptic potentiation mediated by mitochondria
• Proteolytic release of the carboxy-terminal fragment of proHB-EGF caus
• p190RhoGAP is cell cycle regulated and affects cytokinesis
• Evidence for a two membrane–spanning autonomous mitochondrial DNA repl
• p120 catenin associates with kinesin and facilitates the transport of
• Rab27A and its effector MyRIP link secretory granules to F-actin and c
• Defective flagellar assembly and length regulation in LF3 null mutants
• Watching kinetochores sweat
• Cilia take charge in L–R asymmetry
• Exocytosis—one vesicle at a time
• Network architecture determines stability
• Neural progenitors play favorites
• The ER v-SNAREs are required for GPI-anchored protein sorting from oth
• Microtubules are the only structural constituent of the spindle appara
• Loss of Rb launches cell cycle
• Hrs regulates multivesicular body formation via ESCRT recruitment to e
• Importin ? contains a COOH-terminal nucleoporin binding region importa
• Regulation of cell death in mitotic neural progenitor cells by asymmet
• Where mtDNA is made
• ROCK and Rho in 3D
• BMP in a hairy situation
• Quick cartilage transformation
• Forcing cells to stick around
• Cut protein to boost fibers
• Mitochondria to nucleus stress signaling : a distinctive mechanism of
• Proprotein convertase cleavage liberates a fibrillogenic fragment of a
• PMN transendothelial migration decreases nuclear NFB in IL-1?–activate
• Essential functions of p21-activated kinase 1 in morphogenesis and dif
• The elusive cell cycle–transcription link
• Identification of a putative pathway for the muscle homing of stem cel
• A simple way to get cleavage
• When myosin heads go walking
• Schwann cells don caps, touch nodes
• After Hrs with HIV
• Infectious HIV-1 assembles in late endosomes in primary macrophages
• HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein
• Regulation of the expression and processing of caspase-12
• Lipid rafts make for slippery platforms
• Dynamic changes in the osteoclast cytoskeleton in response to growth f
• Direct observation of microtubule dynamics at kinetochores in Xenopus
• Local ERM activation and dynamic growth cones at Schwann cell tips imp
• Vps27 recruits ESCRT machinery to endosomes during MVB sorting
• A mutant heterodimeric myosin with one inactive head generates maximal