Tissue Matching before the Era of HLA Typing
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《新英格兰医药杂志》
To the Editor: In the summer of 1961, I "volunteered" for $50 to receive skin grafts in order to help determine the most suitable bone marrow donor for a teenage girl who was severely anemic as a result of treatment with chloramphenicol. I noted that the mother's graft was rejected in a manner similar to that of the patient's, whereas the brother's graft lasted several more days before rejection occurred and closely retained its larger size and shape (Figure 1). I was told that the girl did not live to receive a transplant. I have carried the scars as a medical curiosity for 40 years.
Figure 1. Early Tissue Typing and Donor Selection — The "Third Man" Technique.
The patient's graft is on the left, the brother's in the center, and the mother's on the right.
David A. Willard, M.D.
Medical Center at Princeton
Princeton, NJ 08540
Figure 1. Early Tissue Typing and Donor Selection — The "Third Man" Technique.
The patient's graft is on the left, the brother's in the center, and the mother's on the right.
David A. Willard, M.D.
Medical Center at Princeton
Princeton, NJ 08540