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Driving in Parkinson’s disease
http://www.100md.com 《神经病学神经外科学杂志》

     Department of Clinical Neurosciences, Royal Free Hospital, University College London, UK

    Correspondence to:

    Dr Anette Schrag

    Department of Clinical Neurosciences, Royal Free Hospital, University College London, London NW3 2QG, UK; a.schrag@medsch.ucl.ac.uk

    It is not possible for patients to predict their driving safety from a motor examination or the patient’s own judgement

    Keywords: Parkinson’s disease; driving

    Patients with Parkinson’s disease are usually advised to inform the driving licensing authority and their driving insurance company of the diagnosis. However, until a few years ago, Parkinson’s disease was not considered a major obstacle to safe driving until the advanced stages. This changed when in 1999 sudden onset sleep attacks in patients with Parkinson’s disease on dopaminergic drugs were first reported.1 This not only led to considerable concern about the safe use of dopaminergic drugs in patients who drive, but also to a flurry of studies investigating the frequency of the problem, the contributing factors, and the mechanism and types of drugs associated with it. However, while this remains an important issue, relatively little attention has been paid to the overall ability and competence of patients with Parkinson’s disease to drive a motor vehicle, unrelated to sleep attacks.

    In this edition of JNNP (see pp 176–80), Wood et al2 address this issue using structured qualitative and quantitative assessments of driving ability in patients with Parkinson’s disease and age matched controls. Experienced, qualified driving assessors who were blinded to the diagnosis found that in a realistic, on road setting, overall driving safety in patients with Parkinson’s disease was significantly impaired; worryingly, a high proportion (more than 50%) of patients would not have passed a state based driving test. The study included 25 patients who had volunteered for the study after attending lectures on the subject, and it is therefore not possible to conclude that such a high percentage of the overall population of patients with Parkinson’s disease would fail a driving test. However, it highlights the potential impairment of driving competence that patients with Parkinson’s disease may experience.

    An important finding was that the driving examiner’s assessment of driving ability correlated poorly with the drivers’ own view of how well they were driving. Poor driving performance also did not correlate with disease severity as measured on clinical scales, although longer disease duration was associated with greater difficulties. No neuropsychological tests were included in the study, but the type of errors made related not only to difficulties in motor tasks but also appeared to be related to the neurocognitive deficits known to occur in Parkinson’s disease.3 Thus, while slowness of movement and reaction time are likely to play important roles in driving performance, other factors such as impaired visuo-spatial processing, planning, and sequencing are also likely to contribute to the difficulties.

    While these results must be confirmed in larger, unselected samples of patients with Parkinson’s disease who are currently driving, the present study not only draws attention to the impairment of driving ability in Parkinson’s disease but also shows that it is not possible for patients to predict their driving safety or to deduce their driving ability from motor examination. While the recommendation to stop driving (or to have a driving assessment) is currently often based on physicians’ overall clinical judgment, this study highlights the need to assess driving ability in Parkinson’s disease regularly and in a standardised fashion. It also calls for studies to explore the motor and non-motor factors leading to impaired driving performance and whether compensatory strategies may help patients improve their driving ability and maintain independence for longer.

    REFERENCES

    Frucht S, Rogers JD, Greene PE, et al. Falling asleep at the wheel: motor vehicle mishaps in persons taking praimpexole and ropinirole. Neurology 1999;52:1908–10.

    Wood JM, Worringham C, Kerr G, et al. Quantitative assessment of driving performance in Parkinson’s disease. J Neurol Neurosurg Psychiatry 2004;75:176–80.

    Emre M. What causes mental dysfunction in Parkinson’s disease? Move Disord 2003;18 (suppl 6) :S63–71.(A Schrag)
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