Efficacy and safety of antidepressants for children and adolescents
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《英国医生杂志》
1 Department of Psychological Medicine, Women's and Children's Hospital, North Adelaide, 5006 SA, Australia, 2 Quality Use of Medicines and Pharmacy Research Centre, University of South Australia, Adelaide, 5000 SA, 3 Department of General Practice, University of Adelaide, Adelaide, 5005 SA, 4 Department of Clinical and Experimental Pharmacology, University of Adelaide, 5 Health Surveillance and Evaluation Section, Public Health, Department of Human Services, Melbourne, 3000 Vic, Australia, 6 University of Wales Academic Unit, Wrexham LL13 7YP
Correspondence to: J N Jureidini jureidinij@wch.sa.gov.au
How safe and effective are antidepressants in children and adolescents? The authors of this review have found disturbing shortcomings in the methods and reporting of trials of newer antidepressants in this patient group
The first 150 words of the full text of this article appear below.
Introduction
Antidepressants introduced since 1990, especially selective serotonin reuptake inhibitors and venlafaxine, have been used increasingly as first line treatment for depression in children.1 2 The safety of prescribing antidepressants to children (including adolescents) has been the subject of increasing concern in the community and the medical profession, leading to recommendations against their use from government and industry (box 1). In this paper, we review the published literature on the efficacy and safety of newer antidepressants in children.
Methods
Having criticised the way in which Keller et al interpreted the results of their study,3 4 we sought to check the quality of methods and reporting of other published trials of newer antidepressants in children (box 2). Of seven published randomised controlled trials of newer antidepressants for depressed children published in refereed journals, six used a placebo control.3 5-9 We analysed each study's methods and the extent to . . .(Jon N Jureidini, head1, C)
Correspondence to: J N Jureidini jureidinij@wch.sa.gov.au
How safe and effective are antidepressants in children and adolescents? The authors of this review have found disturbing shortcomings in the methods and reporting of trials of newer antidepressants in this patient group
The first 150 words of the full text of this article appear below.
Introduction
Antidepressants introduced since 1990, especially selective serotonin reuptake inhibitors and venlafaxine, have been used increasingly as first line treatment for depression in children.1 2 The safety of prescribing antidepressants to children (including adolescents) has been the subject of increasing concern in the community and the medical profession, leading to recommendations against their use from government and industry (box 1). In this paper, we review the published literature on the efficacy and safety of newer antidepressants in children.
Methods
Having criticised the way in which Keller et al interpreted the results of their study,3 4 we sought to check the quality of methods and reporting of other published trials of newer antidepressants in children (box 2). Of seven published randomised controlled trials of newer antidepressants for depressed children published in refereed journals, six used a placebo control.3 5-9 We analysed each study's methods and the extent to . . .(Jon N Jureidini, head1, C)