Ekert and colleagues used growth factor–dependent cell lines to study
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《细胞学杂志》
he cause of cell death in the caspase-deleted cells remains unclear. Mitochondrial ATP generation may be fatally compromised by the leakage of cytochrome c, another mitochondrial factor may leak out, or another caspase may initiate an irreversible event. Whatever the explanation, the current results suggest that the loss of certain caspases in cancer cells does not necessarily explain the increased survival of these cancer cells.(colleagues)