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《细胞学杂志》
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? The Rockefeller University Press, 0021-9525/2002/9/1154-a $5.00
The Journal of Cell Biology, Volume 158, Number 7, September 30, 2002 1154-a-1154
Research Roundup
Semaphorins—not just for axons
Semaphorins (middle) and SF (bottom) both induce invasive growth.
Comoglio/Macmillan
An axon guidance factor can work with growth factor receptors to trigger invasive growth, according to a recent article by Silvia Giordano, Paolo Comoglio, and colleagues (Institute for Cancer Research, University of Torino, Torino, Italy).
The guidance cues are semaphorins, soluble and cell surface molecules that have homology to Met, a scatter factor (SF) receptor tyrosine kinase. Met and semaphorins also share homology with the extracellular domain of semaphorin receptors, known as plexins. Because plexins and semaphorins are expressed outside the nervous system, Giordano et al. examined what function they might control in other tissues.
They found that ligand stimulation of a plexin in epithelial cells caused invasive growth, including scattering and anchorage-independent growth. Met is the only kinase known to trigger invasive growth and, as expected, without Met, this plexin-stimulated growth was blocked. Epithelial cells seem primed for crosstalk between the two receptors, as Met and plexin were in a preformed complex, mediated by their conserved domains. SF and semaphorins in combination produced a stronger response than either alone. "These two modalities of activation can cooperate for certain biological responses but not for others, and this could be a way to fine tune responses such as invasion, without interfering with growth," says Giordano.
Reference:
Giordano, S., et al. 2002. Nat. Cell Biol. 4:720–724.(Published online 23 September)
PDF (Full Text)
Alert me when this article is cited
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Alert me to new content in the JCB
Download to citation manager
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Articles by LeBrasseur, N.
Articles citing this Article
PubMed
Articles by LeBrasseur, N.
? The Rockefeller University Press, 0021-9525/2002/9/1154-a $5.00
The Journal of Cell Biology, Volume 158, Number 7, September 30, 2002 1154-a-1154
Research Roundup
Semaphorins—not just for axons
Semaphorins (middle) and SF (bottom) both induce invasive growth.
Comoglio/Macmillan
An axon guidance factor can work with growth factor receptors to trigger invasive growth, according to a recent article by Silvia Giordano, Paolo Comoglio, and colleagues (Institute for Cancer Research, University of Torino, Torino, Italy).
The guidance cues are semaphorins, soluble and cell surface molecules that have homology to Met, a scatter factor (SF) receptor tyrosine kinase. Met and semaphorins also share homology with the extracellular domain of semaphorin receptors, known as plexins. Because plexins and semaphorins are expressed outside the nervous system, Giordano et al. examined what function they might control in other tissues.
They found that ligand stimulation of a plexin in epithelial cells caused invasive growth, including scattering and anchorage-independent growth. Met is the only kinase known to trigger invasive growth and, as expected, without Met, this plexin-stimulated growth was blocked. Epithelial cells seem primed for crosstalk between the two receptors, as Met and plexin were in a preformed complex, mediated by their conserved domains. SF and semaphorins in combination produced a stronger response than either alone. "These two modalities of activation can cooperate for certain biological responses but not for others, and this could be a way to fine tune responses such as invasion, without interfering with growth," says Giordano.
Reference:
Giordano, S., et al. 2002. Nat. Cell Biol. 4:720–724.(Published online 23 September)