High cholesterol may increase risk of testicular cancer
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《英国医生杂志》
High cholesterol concentrations may increase the risk of testicular cancer, a study has shown. The study investigated the relationship between risk of testicular cancer and blood cholesterol. Researchers found that men with the highest cholesterol concentrations had a cancer risk 4.5 times that for the men with the lowest concentrations.
"The highly significant positive association between serum cholesterol and testicular cancer risk found in this population-based cohort study suggests that an elevated concentration of serum cholesterol is a risk factor for testicular cancer," says a report of the study in the British Journal of Cancer that was published online (ahead of print publication) on 12 April (www.bjcancer.com, doi: 10.1038/sj.bjc.6602539).
Ann-Britt Wiréhn and colleagues from Karolinska University Hospital and Link?ping University, Sweden, used data from a 25 year follow-up study of 44 864 men recruited between 1963 and 1965 as part of a mass screening health trial. Among the measures taken at the time was non-fasting serum cholesterol.
Testicular cancer, which has struck cyclist Lance Armstrong (above), may be connected with high cholesterol concentrations
Credit: CHRISTOPHE ENA/AP
The data were matched with the Swedish cancer registry, the Swedish cause of death registry, and records of cancer registration and death between 1958 and 1987. The national registration system in Sweden using personal code numbers for all residents makes it possible to link registries. Men with any reported cancer before the start of the survey were excluded.
Among the 44 864 men were 21 cases of testicular cancer in the follow-up period. A positive correlation between serum cholesterol concentration and incidence of testicular cancer was found and the estimated hazard ratios calculated for three ranges of cholesterol concentration—below 5.7, 5.7-6.9, and greater than 7.0 mmol/l. The hazard ratios for the middle and highest serum cholesterol categories compared with the lowest were 1.3 (95% confidence interval 0.3 to 5.1) and 4.5 (1.3 to 16.2).
The testes are the commonest site of cancer in men aged 15-44 in Sweden as well as in many other countries. The incidence has increased in recent decades, and a number of possible risk factors have been suggested, including non-descended testes at birth and fat intake.(Roger Dobson)
"The highly significant positive association between serum cholesterol and testicular cancer risk found in this population-based cohort study suggests that an elevated concentration of serum cholesterol is a risk factor for testicular cancer," says a report of the study in the British Journal of Cancer that was published online (ahead of print publication) on 12 April (www.bjcancer.com, doi: 10.1038/sj.bjc.6602539).
Ann-Britt Wiréhn and colleagues from Karolinska University Hospital and Link?ping University, Sweden, used data from a 25 year follow-up study of 44 864 men recruited between 1963 and 1965 as part of a mass screening health trial. Among the measures taken at the time was non-fasting serum cholesterol.
Testicular cancer, which has struck cyclist Lance Armstrong (above), may be connected with high cholesterol concentrations
Credit: CHRISTOPHE ENA/AP
The data were matched with the Swedish cancer registry, the Swedish cause of death registry, and records of cancer registration and death between 1958 and 1987. The national registration system in Sweden using personal code numbers for all residents makes it possible to link registries. Men with any reported cancer before the start of the survey were excluded.
Among the 44 864 men were 21 cases of testicular cancer in the follow-up period. A positive correlation between serum cholesterol concentration and incidence of testicular cancer was found and the estimated hazard ratios calculated for three ranges of cholesterol concentration—below 5.7, 5.7-6.9, and greater than 7.0 mmol/l. The hazard ratios for the middle and highest serum cholesterol categories compared with the lowest were 1.3 (95% confidence interval 0.3 to 5.1) and 4.5 (1.3 to 16.2).
The testes are the commonest site of cancer in men aged 15-44 in Sweden as well as in many other countries. The incidence has increased in recent decades, and a number of possible risk factors have been suggested, including non-descended testes at birth and fat intake.(Roger Dobson)