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Depression and unwanted first pregnancy: longitudinal cohort study
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     1 Department of Psychology UCB 345, University of Colorado, Boulder, CO 80309-0345, USA, 2 Department of Psychology, Arizona State University, Box 871104, Tempe, AZ 85287-1104, USA

    Correspondence to: N F Russo nancy.russo@asu.edu

    Objective To examine the outcomes of an unwanted first pregnancy (abortion v live delivery) and risk of depression and to explain discrepancies with previous research that used the same dataset.

    Design Longitudinal cohort study.

    Setting Nationally representative sample of US men and women aged 14-24 in 1979.

    Participants 1247 women in the US national longitudinal survey of youth who aborted or delivered an unwanted first pregnancy.

    Main outcome measures Clinical cut-off and continuous scores on a 1992 measure of the Center for Epidemiological Studies depression scale.

    Results Terminating compared with delivering an unwanted first pregnancy was not directly related to risk of clinically significant depression (odds ratio 1.19, 95% confidence interval 0.85 to 1.66). No evidence was found of a relation between pregnancy outcome and depression in analyses of subgroups known to vary in under-reporting of abortion. In analyses of the characteristics of non-respondents, refusal to provide information on abortion did not explain the lack of detecting a relation between abortion and mental health. The abortion group had a significantly higher mean education and income and lower total family size, all of which were associated with a lower risk of depression.

    Conclusions Evidence that choosing to terminate rather than deliver an unwanted first pregnancy puts women at higher risk of depression is inconclusive. Discrepancies between current findings and those of previous research using the same dataset primarily reflect differences in coding of a first pregnancy.

    Transition to parenthood is an important and stressful life event that involves multiple risk factors (psychological, marital, and economic) for new mothers,1-3 particularly when they are young4 5 and the pregnancy is unplanned.6 An analysis of the US national longitudinal survey of youth by Reardon and Cougle7 reported that women who abort an unintended first pregnancy are at higher risk of clinical depression than those who carry an unintended first pregnancy to term, and that informed consent should warn women of a higher risk of depression if they elect to terminate an unintended pregnancy.8 The coding and analysis of that trial's data show flaws, however, the most critical of which are misidentification of unwanted first pregnancies and exclusion of women at highest risk of depression associated with early childbearing.

    We examined the relation between the outcome of an unwanted first pregnancy (abortion v live delivery) and depression, unadjusted and adjusted for relevant social and personal factors. These analyses test the same hypotheses as that of Reardon and Cougle,7 but with more precise coding of variables and appropriate criteria for sample selection.

    We then analysed the relation between abortion and depression across groups known to vary in rates of under-reporting of abortion, and we examined the relation between refusals to submit a confidential card containing information on abortion and depression.

    Finally, we examined the possibility of indirect relations between pregnancy outcome and depression through the effect of abortion on social outcomes known to relate to mental health—specifically, education, income, and family size (number of children).

    As in the previous study,7 we selected for pregnancies that were unwanted at the time or not wanted at all. Because these definitions exclude unintended first pregnancies described as wanted or that "didn't matter," we term the pregnancies as unwanted rather than unintended.7

    Methods

    Participants were women from the US national longitudinal survey of youth (NLSY), a national probability sample of civilian men and women aged 14-21 years in 1979, the year the survey began. The figure shows participant flow from the total survey population of 12 686 people to the sample of interest. Of 6283 women, 1820 (29%) were missing data on depression in 1992. Of the 4463 remaining women, 1247 were identified as having an unwanted first pregnancy that ended in a live delivery or abortion. Our sample size is either 1247 or 1004, depending on whether we adjusted for explanatory variables. Year of first pregnancy ranged from 1970 to 1992.

    Participant flow from population of national longitudinal survey of youth to sample of interest

    Construction of variables

    The 1992 Center for Epidemiological Studies depression scale consists of 20 questions, each scaled from 0 (rarely) to 3 (most of the time). Scores potentially range from 0 to 60, with higher scores indicating greater depression. A standard cut-off score dichotomised participants into high (score > 15) or low risk (score 15) categories.7 To more precisely capture the range of depressive symptoms, we carried out parallel analyses using the continuous version of the scale.

    All explanatory variables had been used by Reardon and Cougle7 and all were significantly correlated with outcome measures in both their and our study. Outcome measures included race, age at first pregnancy, and 1992 measures for education, income, and marital status. Education was a continuous variable based on completion of several grades. Income was an ordered categorical variable ranging from 1-10 (for example, 1 was associated with $0-10 000 (£5700; 8316) per year, 2 with $10 001-20 000, and 10 with $90 001 and above). After ensuring no statistically significant differences existed among groups that were never married, divorced, or separated, we dichotomised marital status in 1992 into married or unmarried.

    In keeping with the intent of the Reardon and Cougle study,7 we identified women whose first pregnancy was unwanted and resulted in a live birth or abortion. To ensure accuracy we constructed our variables using coding language provided by staff of the national longitudinal survey of youth. Respondents indicated the outcome of a first ever pregnancy by interview, beginning in 1983 and continuing across subsequent interviews in 1984 and every two years thereafter. At each interview, participants were asked to identify any pregnancies since their last interview and whether or not the pregnancy was wanted (yes, didn't matter, not then, not ever). We then linked the responses to the outcome of first pregnancy. We excluded from the delivery group women who responded with yes or didn't matter. We assumed that first pregnancies terminated by abortion were unwanted unless otherwise specified; we excluded 15 women in the abortion group who reported that their pregnancies were wanted.

    Using this coding approach, we identified a smaller number of eligible women than in the previous study,7 even when compared to the corrected numbers reported (http://bmj.bmjjournals.com/cgi/contentnw/full/324/7345/1097/Ful). As with the previous study, we identified 4463 women with 1992 scores on the Center for Epidemiological Studies depression scale. Both studies seemed to use the same variable to assess whether the pregnancy was wanted; the difference seems to be in the variables used to identify first pregnancy.

    The dataset of the national longitudinal survey of youth is large and complex, with over 100 000 variables. A search using the keyword "pregnancy" yields over 3000 variables. Of these, some refer to pregnancy across the lifespan, some refer to pregnancy since the last interview, some are generated by follow-ups to other questions, and some are constructed from combinations of previous answers. Identification of a first unwanted pregnancy is particularly complex as it involves combining answers to a series of "if then" questions across survey years.

    Contrary to the previous study, we did not exclude women in the delivery group with subsequent abortions. Our stated purpose was to examine the relation between outcome of a first unwanted pregnancy and later depression, and the exclusion of women with subsequent abortions from either abortion or delivery groups would make generalisation to all women with an unwanted first pregnancy inappropriate. It could further be argued that women who have multiple unwanted pregnancies (whether terminated by delivery or abortion) are more likely to be depressed than other women. Consequently, differential exclusion of women from the delivery group on the basis of subsequent abortion creates a bias in favour of finding lower depression in that group. In any case, conclusions of analyses (not reported here) that excluded all women who aborted subsequent pregnancies did not differ from the results reported below.

    Analysis plan

    Analyses were carried out using SAS version 8.2. Before testing the primary study hypotheses, we compared the statistics of the sampling approach used here with that used in the previous study.7 Next we examined the relation between pregnancy outcome and depression. Logistic regression analyses predicted cut-off scores on the depression scale (0 = non-depressed; 1 = depressed) from pregnancy outcome (0 = delivery; 1 = abortion), unadjusted and adjusted for explanatory variables. Odds ratios greater than 1 would indicate greater depression in the abortion group, given the coding pattern of variables. We used ordinary least squares regression for parallel analyses predicting continuous scores for depression.

    It has been suggested that under-reporting of abortion may lead to failures in detecting a link between abortion and depression.7 8 Because under-reporting has been shown to differ across subgroups of individuals (for example, being married, white, and Protestant have been associated with lower under-reporting),9 we examined the relation between pregnancy outcome and depression across the following groups: white versus black married and unmarried women and Catholic versus non-Catholic women. We also addressed the under-reporting of abortion by examining differences in depression between those who did and did not submit the confidential abortion card used by the national longitudinal survey of youth to collect data on abortion. Information on refusals was provided in 1994 and compared with scores on the Center for Epidemiological Studies depression scale. 2 tests were used to compare the cut-off scores for depression within the subgroups; continuous scores were compared using t tests. We examined indirect relations between pregnancy outcome and depression by analyses carried out in two parts: t tests were used to compare mean education, family income, and total number of children across delivery and abortion groups, and logistic and ordinary least squares regression were used to examine the three social variables as predictors of depression scores.

    Results

    The appropriateness of our sampling approach was assessed over that of the previous study for the testing of the research questions. An abbreviated form of the Rotter internal-external locus of control scale was used in the Reardon and Cougle7 study in an attempt to account for "prior psychiatric state." Because this scale was administered in 1979, the authors excluded all women who had experienced their first pregnancy before that time, including most (339 of 425) teenage pregnancies.

    We examined the relation between depression and pregnancy outcome, stratified by a dichotomous variable for year of pregnancy (before 1980 v 1980 and beyond), to statistically compare the two sampling approaches (table 1). We examined the differences in risk of depression among the four groups by using the pre-1980 delivery group as a reference point for comparison with the other three groups. Women in the pre-1980 delivery group had a significantly greater risk of experiencing depression than women in the other three groups.

    Table 1 Proportion of participants in high risk category for depression and mean continuous scores, stratified by pregnancies before 1980 and those occurring from 1980 onwards

    Excluding women with first pregnancies before 1980 consequently removed women at highest risk for negative outcomes associated with early childbearing, making it inappropriate to generalise findings from the previous research to all first pregnancies. Primary analyses for our study were thus based on all women for whom unwanted first pregnancies could be identified. For comparison purposes with Reardon and Cougle's study, we also carried out analyses predicting depression scores from pregnancy outcome on a subsample of women (n = 689) whose pregnancy occurred between 1980 and 1992, adjusting for 1979 Rotter scores.

    Prediction of depression from pregnancy outcome

    Pregnancy outcome did not predict depression scores in either the full sample or in the subsample of pregnancies occurring between 1980 and 1992, even when adjusted for personal and social indicators (table 2). Examination of the raw data confirms similar scores for depression across the delivery and abortion groups, with 28.6% of participants in the delivery group compared with 24.8% in the abortion group being in the high risk category (mean depression scores 11.8 and 10.8, respectively).

    Table 2 Odds ratios (95% confidence intervals) predicting depression cut-off scores from pregnancy outcome and coefficients (SE) showing mean differences in depression continuous scores by pregnancy outcome, in full sample and subsample of post-1979 pregnancies, unadjusted and adjusted for explanatory variables

    Under-reporting of abortion

    We found no evidence for an association between abortion and depression across the subgroups (table 3).

    Table 3 Relation between depression and pregnancy outcome within subpopulations known to vary in amount of under-reporting of abortion

    Among the 4306 women in the larger sample who had both a depression score and abortion card information, 24.5% of women (1025/4190) who submitted the card were in the high risk group compared with 12.9% (15/116) of women in the refusal group (2 = 8.19, P = 0.004). The mean continuous score for the refusal group was significantly lower than that for the group that submitted the card (7.9 v 10.7; t = 2.99, P = 0.003).

    Indirect effects analyses

    We found no evidence that terminating compared with delivering an unwanted first pregnancy changes risk for subsequent depression. This does not mean that the outcome of an unwanted first pregnancy has no relation to risk of depression. The indirect effects of pregnancy outcome on depression were examined, through effects of abortion on income, education, and number of children.

    The abortion group had significantly higher mean education and income and lower total family size (table 4), findings that are consistent with previous analyses of the national longitudinal survey of youth.10

    Table 4 Indirect effect analyses to examine differences in mean (SD) education, income, and family size across delivery and abortion groups and to examine education, income, and family size as predictors of cut-off scores for depression (logistic regression) and continuous scores for depression (ordinary least squares regression)

    Separate regression analyses then examined each social variable (with pregnancy outcome also included in each model) as predictors of depression cut-off and continuous scores (table 4). Higher education and income predicted a lower risk of depression and larger family size predicted a higher risk of depression.

    Discussion

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