2005年(百拇医药)

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2005年

		第1期
		第2期
		第3期
		第4期
		第5期
		第6期
		第7期
		第8期
		第9期
		第10期
		第11期
		第12期

2006年

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2005年


		第1期

07-01-01 Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity

07-01-01 Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair

07-01-01 Identification of cellular deoxyhypusine synthase as a novel target for antiretroviral therapy

07-01-01 SDF-1 is both necessary and sufficient to promote proliferative retinopathy

07-01-01 Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer

07-01-01 Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model

07-01-01 Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics

07-01-01 Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors

07-01-01 IL-7 is a potent and proviral strain–specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAA

07-01-01 CaV2.3 calcium channels control second-phase insulin release

07-01-01 Can antibodies with specificity for soluble antigens mimic the therapeutic effects of intravenous IgG in the treatment of autoimmune disease

07-01-01 Endothelial lipase provides an alternative pathway for FFA uptake in lipoprotein lipase–deficient mouse adipose tissue

07-01-01 Atypical PKC- regulates SDF-1–mediated migration and development of human CD34+ progenitor cells

07-01-01 How to support the basic sciences

07-01-01 Possible involvement of pregnane X receptor–enhanced CYP24 expression in drug-induced osteomalacia


		第2期

07-01-01 Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis

07-01-01 Antiviral chemotherapy facilitates control of poxvirus infections through inhibition of cellular signal transduction

07-01-01 Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation

07-01-01 SOCS2 negatively regulates growth hormone action in vitro and in vivo

07-01-01 5' CArG degeneracy in smooth muscle -actin is required for injury-induced gene suppression in vivo

07-01-01 Anti-A antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice

07-01-01 Macrophage inflammatory protein–1 as a costimulatory signal for mast cell–mediated immediate hypersensitivity reactions

07-01-01 HIV-1–specific CD4+ T lymphocyte turnover and activation increase upon viral rebound

07-01-01 Muscle-specific expression of IGF-1 blocks angiotensin II–induced skeletal muscle wasting

07-01-01 Paget disease of bone

07-01-01 Liver fibrosis

07-01-01 Defining smooth muscle cells and smooth muscle injury

07-01-01 Birth pangs: the stressful origins of lymphocytes

07-01-01 MUNC-ing around with insulin action

07-01-01 MyD88-dependent induction of allergic Th2 responses to intranasal antigen


		第3期

07-01-01 Desperately seeking diversity

07-01-01 Gestational diabetes mellitus

07-01-01 Learning from failure: congestive heart failure in the postgenomic age

07-01-01 Oxygen, oxidative stress, hypoxia, and heart failure

07-01-01 NO/redox disequilibrium in the failing heart and cardiovascular system

07-01-01 Genetic causes of human heart failure

07-01-01 Toward transcriptional therapies for the failing heart: chemical screens to modulate genes

07-01-01 Protein kinase cascades in the regulation of cardiac hypertrophy

07-01-01 Mitochondrial energy metabolism in heart failure: a question of balance

07-01-01 Altered intracellular Ca2+ handling in heart failure

07-01-01 Death begets failure in the heart

07-01-01 Unchain my heart: the scientific foundations of cardiac repair

07-01-01 Genetic mouse models of essential tremor: are they essential?

07-01-01 Illuminating the role of type I IFNs in colitis

07-01-01 Genetic essential tremor in -aminobutyric acidA receptor 1 subunit knockout mice


		第4期

07-01-01 Intravesical administration of small interfering RNA targeting PLK-1 successfully prevents the growth of bladder cancer

07-01-01 Differential impact of prostaglandin H synthase 1 knockdown on platelets and parturition

07-01-01 Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV

07-01-01 The MODY1 gene HNF-4 regulates selected genes involved in insulin secretion

07-01-01 Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase–1

07-01-01 Bcl-2–related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury

07-01-01 Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells

07-01-01 Role of osteopontin in amplification and perpetuation of rheumatoid synovitis

07-01-01 The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells

07-01-01 Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS

07-01-01 Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system

07-01-01 Sex and the university system

07-01-01 The several Cs of translational clinical research

07-01-01 Immunopathogenesis and therapy of cutaneous T cell lymphoma

07-01-01 Lack of MEF2A mutations in coronary artery disease


		第5期

07-01-01 Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity

07-01-01 Severe impairment in liver insulin signaling fails to alter hepatic insulin action in conscious mice

07-01-01 Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action

07-01-01 Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I

07-01-01 Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

07-01-01 Identification of Epstein-Barr virus proteins as putative targets of the immune response in multiple sclerosis

07-01-01 Virus-induced dysfunction of CD4+CD25+ T cells in patients with HTLV-I–associated neuroimmunological disease

07-01-01 Raising consciousness

07-01-01 Inflammation, stress, and diabetes

07-01-01 The role of cerebral amyloid accumulation in common forms of Alzheimer disease

07-01-01 Food for thought: endocannabinoid modulation of lipogenesis

07-01-01 Chemokine-mediated angiogenesis: an essential link in the evolution of airway fibrosis

07-01-01 The role of hepatic insulin receptors in the regulation of glucose production

07-01-01 Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease

07-01-01 Regulation of CD1d expression and function by a herpesvirus infection


		第6期

07-01-01 Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

07-01-01 FGF-21 as a novel metabolic regulator

07-01-01 Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reacti

07-01-01 HS1 protein is differentially expressed in chronic lymphocytic leukemia patient subsets with good or poor prognoses

07-01-01 Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia

07-01-01 Do you have NIH funding Then read this.

07-01-01 Mapping the new frontier: complex genetic disorders

07-01-01 Factors affecting statistical power in the detection of genetic association

07-01-01 Mapping quantitative trait loci in humans: achievements and limitations

07-01-01 Linkage disequilibrium maps and association mapping

07-01-01 Genetic epidemiology of diabetes

07-01-01 Finding schizophrenia genes

07-01-01 The genetic eidemiology of neurodegenerative disease

07-01-01 Atrial natriuretic etide: an essential hysiological regulator of transvascular fluid, rotein transort, and lasma volume

07-01-01 Role of leptin and melanocortin signaling in uremia-associated cachexia


		第7期

07-01-01 Fertility in luteinizing hormone receptor-knockout mice after wild-type ovary transplantation demonstrates redundancy of extragonadal lutein

07-01-01 T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cells

07-01-01 Developmental control of CD8+ T cell–avidity maturation in autoimmune diabetes

07-01-01 Functional, structural, and metabolic abnormalities of the hippocampal formation in Williams syndrome

07-01-01 Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates

07-01-01 Targeting the local tumor microenvironment with vaccinia virus expressing B7.1 for the treatment of melanoma

07-01-01 Liver X receptors and regulate renin expression in vivo

07-01-01 Oral tolerance in the absence of naturally occurring Tregs

07-01-01 Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor

07-01-01 Payment of clinical research subjects

07-01-01 Entry of parainfluenza virus into cells as a target for interrupting childhood respiratory disease

07-01-01 Skeletal muscle fat oxidation: timing and flexibility are everything

07-01-01 HIF-1: a master regulator of innate host defenses

07-01-01 Bone marrow plasticity revisited: protection or differentiation in the kidney tubule

07-01-01 Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog


		第8期

07-01-01 Thyrotropin receptor–associated diseases: from adenomata to Graves disease

07-01-01 The channelopathies: novel insights into molecular and genetic mechanisms of human disease

07-01-01 Inherited disorders of voltage-gated sodium channels

07-01-01 Muscle channelopathies and critical points in functional and genetic studies

07-01-01 Sodium channel mutations in epilepsy and other neurological disorders

07-01-01 Long QT syndrome: from channels to cardiac arrhythmias

07-01-01 Genetics of acquired long QT syndrome

07-01-01 Cardiac and skeletal muscle disorders caused by mutations in the intracellular Ca2+ release channels

07-01-01 Chloride channel diseases resulting from impaired transepithelial transport or vesicular function

07-01-01 ATP-sensitive potassium channelopathies: focus on insulin secretion

07-01-01 Akt1 in the cardiovascular system: friend or foe

07-01-01 A new direction for gene therapy: intrathymic T cell–specific lentiviral gene transfer

07-01-01 Spring brings breezes, wheezes, and pollen oxidases

07-01-01 Insulin infusion in acute illness

07-01-01 Intensive insulin therapy protects the endothelium of critically ill patients


		第9期

07-01-01 Schoenheimer effect explained – feedback regulation of cholesterol synthesis in mice mediated by Insig proteins

07-01-01 Blood-brain barrier invasion by group B Streptococcus depends upon proper cell-surface anchoring of lipoteichoic acid

07-01-01 Ets-1 is a critical regulator of Ang II-mediated vascular inflammation and remodeling

07-01-01 Negative regulation by thyroid hormone receptor requires an intact coactivator-binding surface

07-01-01 Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans

07-01-01 Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal injury in SIV neuroAIDS

07-01-01 Tonsillar homing of Epstein-Barr virus–specific CD8+ T cells and the virus-host balance

07-01-01 Alzheimer disease -amyloid activity mimics cholesterol oxidase

07-01-01 Mechanisms of sudden cardiac death

07-01-01 The crucial role of macrophages in lymphangiogenesis

07-01-01 Searching for transcriptional regulators of Ang II–induced vascular pathology

07-01-01 Osteoblast-derived PTHrP is a physiological regulator of bone formation

07-01-01 Anchors away: contribution of a glycolipid anchor to bacterial invasion of host cells

07-01-01 Activation or anergy: NKT cells are stunned by -galactosylceramide

07-01-01 Small-molecule correctors of defective F508-CFTR cellular processing identified by high-throughput screening


		第10期

07-01-01 Kidney stone disease

07-01-01 Pharmacological manipulation of cell death: clinical applications in sight

07-01-01 The survival kinases Akt and Pim as potential pharmacological targets

07-01-01 IKK/NF-B signaling: balancing life and death – a new approach to cancer therapy

07-01-01 Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathways

07-01-01 Mitochondria: pharmacological manipulation of cell death

07-01-01 Pharmacological manipulation of Bcl-2 family members to control cell death

07-01-01 Endoplasmic reticulum stress: cell life and death decisions

07-01-01 Caspases: pharmacological manipulation of cell death

07-01-01 Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP function

07-01-01 Autophagy in cell death: an innocent convict

07-01-01 Mining yeast in silico unearths a golden nugget for mitochondrial biology

07-01-01 PDGF signaling in pulmonary arterial hypertension

07-01-01 Give me A5 for lipoprotein hydrolysis!

07-01-01 Arsenic trioxide inhibits nuclear receptor function via SEK1/JNK-mediated RXR phosphorylation


		第11期

07-01-01 Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4+ T lymphocytes

07-01-01 Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor– viral RNA interactions

07-01-01 The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs

07-01-01 B cells: no longer bystanders in liver fibrosis

07-01-01 CD36 may determine our desire for dietary fats

07-01-01 All neuropathies great and small

07-01-01 When 7 transmembrane receptors are not G protein–coupled receptors

07-01-01 Variable phenotypic expression of mutations in genes of the immune system

07-01-01 New insights into nNOS regulation of vascular homeostasis

07-01-01 Infiltration of COX-2–expressing macrophages is a prerequisite for IL-1–induced neovascularization and tumor growth

07-01-01 Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin

07-01-01 Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction

07-01-01 A cancer-specific transcriptional signature in human neoplasia

07-01-01 Disease-related phenotypes in a Drosophila model of hereditary spastic paraplegia are ameliorated by treatment with vinblastine

07-01-01 P-glycoprotein deficiency at the blood-brain barrier increases amyloid- deposition in an Alzheimer disease mouse model


		第12期

07-01-01 Identification of human urinary trefoil factor 1 as a novel calcium oxalate crystal growth inhibitor

07-01-01 The L-type calcium channel in the heart: the beat goes on

07-01-01 Pathogenesis of osteoporosis: concepts, conflicts, and prospects

07-01-01 Did dinosaurs have megakaryocytes New ideas about platelets and their progenitors

07-01-01 Megakaryocyte biology and related disorders

07-01-01 The molecular mechanisms that control thrombopoiesis

07-01-01 The biogenesis of platelets from megakaryocyte proplatelets

07-01-01 Thrombus formation in vivo

07-01-01 Structure and function of the platelet integrin IIb3

07-01-01 Platelet genomics and proteomics in human health and disease

07-01-01 Platelets in inflammation and atherogenesis

07-01-01 Minding the gaps to promote thrombus growth and stability

07-01-01 Is ghrelin a signal for the development of metabolic systems

07-01-01 Expanding the immunotherapeutic potential of minor histocompatibility antigens

07-01-01 Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells