2006年(百拇医药)

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2005年

2006年

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		第2期
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		第4期
		第5期
		第6期
		第7期
		第8期
		第9期
		第10期
		第11期
		第12期

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2006年


		第1期

07-01-01 IAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas

07-01-01 Aberrant maturation of mutant perforin underlies the clinical diversity of hemophagocytic lymphohistiocytosis

07-01-01 Anti-A42- and anti-A40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model

07-01-01 Intramuscular viral delivery of paraplegin rescues peripheral axonopathy in a model of hereditary spastic paraplegia

07-01-01 Soy diet worsens heart disease in mice

07-01-01 Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice

07-01-01 Neuronal eotaxin and the effects of ccr3 antagonist on airway hyperreactivity and M2 receptor dysfunction

07-01-01 Controlled delivery of PDGF-BB for myocardial protection using injectable self-assembling peptide nanofibers

07-01-01 Characterization and isolation of stem cell–enriched human hair follicle bulge cells

07-01-01 Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities

07-01-01 Taking a bite out of hypertrophic cardiomyopathy: soy diet and disease

07-01-01 Gene expression profiling gets to the root of human hair follicle stem cells

07-01-01 Delving deeper into MALT lymphoma biology

07-01-01 Serum peptidome for cancer detection: spinning biologic trash into diagnostic gold

07-01-01 B-Crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer


		第2期

07-01-01 Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions

07-01-01 Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis

07-01-01 Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis

07-01-01 Peptide vaccination of mice immune to LCMV or vaccinia virus causes serious CD8+ T cell-mediated, TNF-dependent immunopathology

07-01-01 Type 3 deiodinase is critical for the maturation and function of the thyroid axis

07-01-01 Toll-like receptor 2 controls expansion and function of regulatory T cells

07-01-01 Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice

07-01-01 Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin

07-01-01 Cell-derived anaphylatoxins as key mediators of antibody-dependent type II autoimmunity in mice

07-01-01 Insulin’s direct effects on the liver dominate the control of hepatic glucose production

07-01-01 Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes

07-01-01 SIDS: genetic and environmental influences may cause arrhythmia in this silent killer

07-01-01 Gastrointestinal motility and glycemic control in diabetes: the chicken and the egg revisited

07-01-01 Insulin’s effect on the liver: "Direct or indirect" continues to be the question

07-01-01 Fos protein as a target of anti-osteoclastogenic action of vitamin D, and synthesis of new analogs


		第3期

07-01-01 Elastin fragments drive disease progression in a murine model of emphysema

07-01-01 Role of the forkhead protein FoxO1 in ? cell compensation to insulin resistance

07-01-01 Platelet-derived or soluble CD154 induces vascularized allograft rejection independent of cell-bound CD154

07-01-01 A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma

07-01-01 CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney

07-01-01 Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice

07-01-01 Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases

07-01-01 Going nuclear in metabolic and cardiovascular disease

07-01-01 Sorting out the roles of PPAR in energy metabolism and vascular homeostasis

07-01-01 PPAR and human metabolic disease

07-01-01 PPAR: a dagger in the heart of the metabolic syndrome

07-01-01 Liver X receptors as integrators of metabolic and inflammatory signaling

07-01-01 Involvement of PPAR nuclear receptors in tissue injury and wound repair

07-01-01 PGC-1 coactivators: inducible regulators of energy metabolism in health and disease

07-01-01 Cholinergic dysfunction in a mouse model of Alzheimer disease is reversed by an anti-A antibody


		第4期

07-01-01 Intestinal ABCA1 directly contributes to HDL biogenesis in vivo

07-01-01 Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion

07-01-01 Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation

07-01-01 Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats

07-01-01 The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responses

07-01-01 Farnesoid X receptor is essential for normal glucose homeostasis

07-01-01 Rescuing the NIH before it is too late

07-01-01 Harnessing preclinical mouse models to inform human clinical cancer trials

07-01-01 Childhood lead poisoning: the torturous path from science to policy

07-01-01 Adult T cell leukemia: a tale of two T cells

07-01-01 Oxidative stress in sepsis: a redox redux

07-01-01 The alchemy of tendon repair: a primer for the (S)mad scientist

07-01-01 A new cardiac MASTer switch for the renin-angiotensin system

07-01-01 Pathomechanisms in rheumatoid arthritis — time for a string theory

07-01-01 An unexpected role for angiotensin II in the link between dietary salt and proximal reabsorption


		第5期

07-01-01 The stem cell niches in bone

07-01-01 Regulation of bone mass by Wnt signaling

07-01-01 Bypassing complement: evolutionary lessons and future implications

07-01-01 The IL-23/IL-17 axis in inflammation

07-01-01 Role of caveolin-1 in the regulation of the vascular shear stress response

07-01-01 Putting cholesterol in its place: apoE and reverse cholesterol transport

07-01-01 Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair

07-01-01 Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response

07-01-01 "Viral deja vu" elicits organ-specific immune disease independent of reactivity to self

07-01-01 The human herpesvirus 8 chemokine receptor vGPCR triggers autonomous proliferation of endothelial cells

07-01-01 Adenosine metabolism and murine strain–specific IL-4–induced inflammation, emphysema, and fibrosis

07-01-01 Direct evidence for the role of caveolin-1 and caveolae in mechanotransduction and remodeling of blood vessels

07-01-01 Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice

07-01-01 Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors

07-01-01 Receptor heterodimerization: a new level of cross-talk


		第6期

07-01-01 Critical role of stearoyl-CoA desaturase–1 (SCD1) in the onset of diet-induced hepatic insulin resistance

07-01-01 Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel

07-01-01 Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia

07-01-01 Defective regulatory and effector T cell functions in patients with FOXP3 mutations

07-01-01 Rescuing the NIH: the response

07-01-01 Response to: "Rescuing the NIH before it is too late"

07-01-01 Planning science (a generation after Lewis Thomas)

07-01-01 Response to: "Rescuing the NIH before it is too late" from the Deputy Director for Extramural Research

07-01-01 Cardiac hypertrophy: stressing out the heart

07-01-01 Mechanisms of sympathoadrenal failure and hypoglycemia in diabetes

07-01-01 IPEX and the role of FOXP3 in the development and function of human Tregs

07-01-01 Of mice, men, and elephants: Mycobacterium tuberculosis cell envelope lipids and pathogenesis

07-01-01 Probing the role of stearoyl-CoA desaturase_1 in hepatic insulin resistance

07-01-01 Cryptococcal virulence: beyond the usual suspects

07-01-01 Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia- induced hormonal counterregulation


		第7期

06-07-27 Tracking the recovery of consciousness from coma

06-07-27 World-class IIa HDACs control cardiac growth

06-07-27 The IL-21 receptor augments Th2 effector function and alternative macrophage activation

06-07-27 The leak stops here: platelets as delivery vehicles for coagulation factors

06-07-27 Stop misbehaving!

06-07-27 Suppression of canonical Wnt/?-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomy

06-07-27 Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake

06-07-27 Neuropeptide signaling and hydrocephalus: SCO with the flow

06-07-27 Possible axonal regrowth in late recovery from the minimally conscious state

06-07-27 Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity

06-07-27 Insulin resistance and pancreatic ? cell failure

06-07-27 Islet ? cell failure in type 2 diabetes

06-07-27 Liver X receptor opens a new gateway to StAR and to steroid hormones

06-07-27 Liver X receptors regulate adrenal cholesterol balance

06-07-27 KSHV targets multiple leukocyte lineages during long-term productive infection in NOD/SCID mice


		第8期

07-01-01 Nicotine induces cell proliferation by -arrestin–mediated activation of Src and Rb–Raf-1 pathways

07-01-01 Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice

07-01-01 HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease

07-01-01 A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG ODN–based vaginal microbicide

07-01-01 Anaphylactic shock depends on PI3K and eNOS-derived NO

07-01-01 Inhibition of T cell activation and autoimmune diabetes using a B cell surface–linked CTLA-4 agonist

07-01-01 MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals

07-01-01 Proteinuria precedes podocyte abnormalities inLamb2–/– mice, implicating the glomerular basement membrane as an albumin barrier

07-01-01 Mutual repression between steroid and xenobiotic receptor and NF-B signaling pathways links xenobiotic metabolism and inflammation

07-01-01 The Clinical Research Forum and Association of American Physicians disagree with criticism of the NIH Roadmap

07-01-01 Resurrection of vitamin D deficiency and rickets

07-01-01 Gout: new insights into an old disease

07-01-01 What’s in a name eNOS and anaphylactic shock

07-01-01 HIV and CXCR4 in a kiss of autophagic death

07-01-01 Antisense oligonucleotide therapy for neurodegenerative disease


		第9期

07-01-01 Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans

07-01-01 Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling

07-01-01 Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism

07-01-01 FcRIII engagement provides activating signals to NKT cells in antibody-induced joint inflammation

07-01-01 The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity

07-01-01 TRAIL receptor–mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality

07-01-01 Bone protection by estrens occurs through non–tissue-selective activation of the androgen receptor

07-01-01 Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycar

07-01-01 PTEN inhibits IL-2 receptor–mediated expansion of CD4+ CD25+ Tregs

07-01-01 Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M

07-01-01 Supporting junior faculty in the academic system: time for a change

07-01-01 A mighty mouse: building a better model of multiple sclerosis

07-01-01 Regeneration of the endothelium as a novel therapeutic strategy for acute lung injury

07-01-01 Toll-like receptors and IFN-: partners in autoimmunity

07-01-01 Relating TCR-peptide-MHC affinity to immunogenicity for the design of tumor vaccines


		第10期

07-01-16 Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect

07-01-16 VSIG4, a B7 family–related protein, is a negative regulator of T cell activation

07-01-01 Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo

07-01-01 Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer

07-01-01 Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations

07-01-01 TAT-mediated intracellular delivery of purine nucleoside phosphorylase corrects its deficiency in mice

07-01-01 Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling

07-01-01 Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease

07-01-01 Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion

07-01-01 CXCR2 ligands and G-CSF mediate PKC-induced intraepidermal inflammation

07-01-01 Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells

07-01-01 Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect

07-01-01 Endocarditis and biofilm-associated pili of Enterococcus faecalis

07-01-01 The physician-scientist, the state, and the oath: thoughts for our times

07-01-01 T cell activation altersintestinal structure and function


		第11期

07-01-16 NF-B regulation of endothelial cell function during LPS-induced toxemia and cancer

07-01-16 NF-B2 is required for the establishment of central tolerance through an Aire-dependent pathway

07-01-16 Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone receptor inhibits mitotic progression

07-01-16 Mutation of -glucosidase 2 causes glycolipid storage disease and impaired male fertility

07-01-16 Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and inlivers of parabiotic mice

07-01-16 Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection

07-01-16 TLR4 links innate immunity and fatty acid–induced insulin resistance

07-01-16 Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan-mediated neointimal formation in the ductus arteriosus

07-01-16 Rai1 duplication causes physical and behavioral phenotypes in a mouse model of dup(17)(p11.2p11.2)

07-01-16 Impaired regulation of NF-B and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice

07-01-16 Toll-like receptor 4 deficiency causes pulmonary emphysema

07-01-16 Can I quote you on that

07-01-16 Drug discovery in jeopardy

07-01-16 Myasthenia gravis: past, present, and future

07-01-16 Deficiency in neuronal TGF- signaling promotes neurodegeneration and Alzheimer’s pathology


		第12期

07-01-16 Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels

07-01-16 Cytokine-induced differentiation of multipotent adult progenitor cells into functional smooth muscle cells

07-01-16 Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts

07-01-16 Indoleamine 2,3-dioxygenase–expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection

07-01-16 Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and Bcl2A1 as critical target genes

07-01-16 Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis

07-01-16 Proteasome-mediated degradation of IB and processing of p105 in Crohn disease and ulcerative colitis

07-01-16 Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation

07-01-16 Rosiglitazone promotes development of a novel adipocyte population from bone marrow–derived circulating progenitor cells

07-01-16 Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice

07-01-16 Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite

07-01-16 Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B–null mice

07-01-16 Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis

07-01-16 Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP

07-01-16 Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy