2005年(百拇医药)

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2005年

		第1期
		第2期
		第3期
		第4期
		第5期
		第6期
		第7期
		第8期
		第9期
		第10期
		第11期
		第12期

2006年

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2005年


		第1期

07-01-01 Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription : implications for the epithelial–mesenchymal transition

07-01-01 MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A

07-01-01 Condensed mitotic chromatin is accessible to transcription factors and chromatin structural proteins

07-01-01 p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2

07-01-01 Identification of cytoplasmic residues of Sec61p involved in ribosome binding and cotranslational translocation

07-01-01 Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER

07-01-01 HECT ubiquitin ligases link viral and cellular PPXY motifs to the vacuolar protein-sorting pathway

07-01-01 Mdm31 and Mdm32 are inner membrane proteins required for maintenance of mitochondrial shape and stability of mitochondrial DNA nucleoids in

07-01-01 The PSD95–nNOS interface : a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death

07-01-01 RPTP is essential for NCAM-mediated p59fyn activation and neurite elongation

07-01-01 CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex

07-01-01 Going in GTP cycles in the nucleolus

07-01-01 A multistep, GTP-driven mechanism controlling the dynamic cycling of nucleostemin

07-01-01 Cell growth–dependent coordination of lipid signaling and glycosylation is mediated by interactions between Sac1p and Dpm1p

07-01-01 Ultrastructural identification of uncoated caveolin-independent early endocytic vehicles


		第2期

07-01-01 Conservation of boundary extension mechanisms between plants and animals

07-01-01 Crossing over is coupled to late meiotic prophase bivalent differentiation through asymmetric disassembly of the SC

07-01-01 Long-range cooperative binding of kinesin to a microtubule in the presence of ATP

07-01-01 Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments

07-01-01 PATJ regulates tight junction formation and polarity in mammalian epithelial cells

07-01-01 The de novo centriole assembly pathway in HeLa cells : cell cycle progression and centriole assembly/maturation

07-01-01 Bcl-XL specifically activates Bak to induce swelling and restructuring of the endoplasmic reticulum

07-01-01 Cog3p depletion blocks vesicle-mediated Golgi retrograde trafficking in HeLa cells

07-01-01 N-myristoylation determines dual targeting of mammalian NADH-cytochrome b(5) reductase to ER and mitochondrial outer membranes by a mechanis

07-01-01 Dynamic ergosterol- and ceramide-rich domains in the peroxisomal membrane serve as an organizing platform for peroxisome fusion

07-01-01 Sunday Driver links axonal transport to damage signaling

07-01-01 A Sec14p-nodulin domain phosphatidylinositol transfer protein polarizes membrane growth of Arabidopsis thaliana root hairs

07-01-01 organization by self-organization : mechanisms and models for Min protein dynamics

07-01-01 Protein synthesis persists during necrotic cell death

07-01-01 Regulation of the interaction between PIPKI and talin by proline-directed protein kinases


		第3期

07-01-01 1 integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation

07-01-01 The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability

07-01-01 Three-dimensional EM structure of the ectodomain of integrin V3 in a complex with fibronectin

07-01-01 The AAA+ protein torsinA interacts with a conserved domain present in LAP1 and a novel ER protein

07-01-01 -site specific intrabodies to decrease and prevent generation of Alzheimer's A peptide

07-01-01 TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity

07-01-01 Chromatin decondensation in S-phase involves recruitment of Cdk2 by Cdc45 and histone H1 phosphorylation

07-01-01 Activity-dependent and -independent nuclear fluxes of HDAC4 mediated by different kinases in adult skeletal muscle

07-01-01 The high mobility group transcription factor Sox8 is a negative regulator of osteoblast differentiation

07-01-01 Inhibition of NGF deprivation–induced death by low oxygen involves suppression of BIMEL and activation of HIF-1

07-01-01 Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles

07-01-01 Two modes of exocytosis at hippocampal synapses revealed by rate of FM1-43 efflux from individual vesicles

07-01-01 ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles

07-01-01 Raf-1 regulates Rho signaling and cell migration

07-01-01 A small surface hydrophobic stripe in the coiled-coil domain of type I keratins mediates tetramer stability


		第4期

07-01-01 In vitro assembly and GTP hydrolysis by bacterial tubulins BtubA and BtubB

07-01-01 Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2

07-01-01 eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3'UTR

07-01-01 Transcriptional regulation of myotube fate specification and intrafusal muscle fiber morphogenesis

07-01-01 Deep-etch EM reveals that the early poxvirus envelope is a single membrane bilayer stabilized by a geodetic "honeycomb" surface coat

07-01-01 Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis

07-01-01 Efficient formation of bipolar microtubule bundles requires microtubule-bound -tubulin complexes

07-01-01 Neural crest stem cell maintenance by combinatorial Wnt and BMP signaling

07-01-01 A developmentally regulated Na-H exchanger in Dictyostelium discoideum is necessary for cell polarity during chemotaxis

07-01-01 Phosphorylation of p66Shc and forkhead proteins mediates A toxicity

07-01-01 Achlorhydria by ezrin knockdown : defects in the formation/expansion of apical canaliculi in gastric parietal cells

07-01-01 N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis

07-01-01 Proteomic and genomic characterization of chromatin complexes at a boundary

07-01-01 ZW10 links mitotic checkpoint signaling to the structural kinetochore

07-01-01 Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth


		第5期

07-01-01 Endoplasmic reticulum stress signaling transmitted by ATF6 mediates apoptosis during muscle development

07-01-01 A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice

07-01-01 Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity

07-01-01 FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice

07-01-01 Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-

07-01-01 Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain

07-01-01 SEC18/NSF-independent, protein-sorting pathway from the yeast cortical ER to the plasma membrane

07-01-01 Palmitoylation regulates plasma membrane–nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family

07-01-01 Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells

07-01-01 Junctional membrane inositol 1,4,5-trisphosphate receptor complex coordinates sensitization of the silent EGF-induced Ca2+ signaling

07-01-01 Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases : implications for mutant huntingtin toxicity

07-01-01 Coatomer-bound Cdc42 regulates dynein recruitment to COPI vesicles

07-01-01 Capacitative calcium entry : sensing the calcium stores

07-01-01 MCAK associates with the tips of polymerizing microtubules

07-01-01 Structurally and functionally unique complexins at retinal ribbon synapses


		第6期

07-01-01 Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration

07-01-01 A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells

07-01-01 -Syntrophin regulates ARMS localization at the neuromuscular junction and enhances EphA4 signaling in an ARMS-dependent manner

07-01-01 Unzipped and loaded : the role of DNA helicases and RFC clamp-loading complexes in sister chromatid cohesion

07-01-01 Epigenetic manipulation of gene expression : a toolkit for cell biologists

07-01-01 Histone H1 is essential for mitotic chromosome architecture and segregation in Xenopus laevis egg extracts

07-01-01 Stress granules and processing bodies are dynamically linked sites of mRNP remodeling

07-01-01 G protein interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus

07-01-01 Septin-dependent compartmentalization of the endoplasmic reticulum during yeast polarized growth

07-01-01 A positive feedback loop between Dumbfounded and Rolling pebbles leads to myotube enlargement in Drosophila

07-01-01 Musculin/MyoR is expressed in kidney side population cells and can regulate their function

07-01-01 Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3 in migrating epithelial cells

07-01-01 Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryog

07-01-01 The exocyst component Sec5 is present on endocytic vesicles in the oocyte of Drosophila melanogaster

07-01-01 Quantitative electron microscopy and fluorescence spectroscopy of the membrane distribution of influenza hemagglutinin


		第7期

07-01-01 FcRI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane

07-01-01 Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors

07-01-01 Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

07-01-01 Meiotic telomere clustering requires actin for its formation and cohesin for its resolution

07-01-01 The nuclear pore complex–associated protein, Mlp2p, binds to the yeast spindle pole body and promotes its efficient assembly

07-01-01 The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria

07-01-01 SNAREs can promote complete fusion and hemifusion as alternative outcomes

07-01-01 Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway

07-01-01 Lethal giant larvae proteins interact with the exocyst complex and are involved in polarized exocytosis

07-01-01 Src-like adaptor protein down-regulates T cell receptor (TCR)–CD3 expression by targeting TCR for degradation

07-01-01 JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3

07-01-01 Adenovirus E4orf6 targets pp32/LANP to control the fate of ARE-containing mRNAs by perturbing the CRM1-dependent mechanism

07-01-01 Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor–B activation in muramyl dipeptide recognition

07-01-01 Early encounters of a nascent membrane protein : specificity and timing of contacts inside and outside the ribosome

07-01-01 A novel role for Gab2 in bFGF-mediated cell survival during retinoic acid–induced neuronal differentiation


		第8期

07-01-01 Dynamic formation of RecA filaments at DNA double strand break repair centers in live cells

07-01-01 Mammalian WDR12 is a novel member of the Pes1–Bop1 complex and is required for ribosome biogenesis and cell proliferation

07-01-01 Identification of FIP200 interaction with the TSC1–TSC2 complex and its role in regulation of cell size control

07-01-01 Viruses activate a genetically conserved cell death pathway in a unicellular organism

07-01-01 The limited role of NH2-terminal c-Jun phosphorylation in neuronal apoptosis : Identification of the nuclear pore complex as a potential tar

07-01-01 Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation

07-01-01 Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulin

07-01-01 The Rho kinases I and II regulate different aspects of myosin II activity

07-01-01 The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex

07-01-01 Essential role of CIB1 in regulating PAK1 activation and cell migration

07-01-01 Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain

07-01-01 The epidermal barrier function is dependent on the serine protease CAP1/Prss8

07-01-01 Dendrite development : a surprising origin

07-01-01 FAPP2 is involved in the transport of apical cargo in polarized MDCK cells

07-01-01 CEACAM engagement by human pathogens enhances cell adhesion and counteracts bacteria-induced detachment of epithelial cells


		第9期

07-01-01 Dnm1 forms spirals that are structurally tailored to fit mitochondria

07-01-01 The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex

07-01-01 Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis

07-01-01 Aurora A activates D-TACC–Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules

07-01-01 Function and regulation of Maskin, a TACC family protein, in microtubule growth during mitosis

07-01-01 Ganglioside-induced differentiation associated protein 1 is a regulator of the mitochondrial network : new implications for Charcot-Marie-To

07-01-01 Selective role for superoxide in InsP3 receptor–mediated mitochondrial dysfunction and endothelial apoptosis

07-01-01 The vacuolar DHHC-CRD protein Pfa3p is a protein acyltransferase for Vac8p

07-01-01 Lithium induces autophagy by inhibiting inositol monophosphatase

07-01-01 PKA-catalyzed phosphorylation of tomosyn and its implication in Ca2+-dependent exocytosis of neurotransmitter

07-01-01 Neurotransmitter release regulated by a MALS–liprin- presynaptic complex

07-01-01 Cardiac neural crest cells contribute to the dormant multipotent stem cell in the mammalian heart

07-01-01 LIS-less neurons don't even make it to the starting gate

07-01-01 Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling

07-01-01 Spines and neurite branches function as geometric attractors that enhance protein kinase C action


		第10期

07-01-01 Termination of cAMP signals by Ca2+ and Gi via extracellular Ca2+ sensors : a link to intracellular Ca2+ oscillations

07-01-01 Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain

07-01-01 Mitogen-inducible gene 6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth

07-01-01 Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane

07-01-01 Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration

07-01-01 Cell surface counter receptors are essential components of the unconventional export machinery of galectin-1

07-01-01 A generation in autophagic vacuoles

07-01-01 The 70-kD heat shock cognate protein (hsc70) facilitates the nuclear export of the import receptors

07-01-01 Rootletin forms centriole-associated filaments and functions in centrosome cohesion

07-01-01 Cdc25B cooperates with Cdc25A to induce mitosis but has a unique role in activating cyclin B1–Cdk1 at the centrosome

07-01-01 Microdomains bounded by endoplasmic reticulum segregate cell cycle calcium transients in syncytial Drosophila embryos

07-01-01 Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor

07-01-01 Structural properties and neuronal toxicity of amyotrophic lateral sclerosis–associated Cu/Zn superoxide dismutase 1 aggregates

07-01-01 Macroautophagy—a novel -amyloid peptide-generating pathway activated in Alzheimer's disease

07-01-01 The mechanisms and dynamics of v3 integrin clustering in living cells


		第11期

07-01-01 Coordinated transport of phosphorylated amyloid- precursor protein and c-Jun NH2-terminal kinase–interacting protein-1

07-01-01 Spore number control and breeding in Saccharomyces cerevisiae : a key role for a self-organizing system

07-01-01 The cell cycle–apoptosis connection revisited in the adult brain

07-01-01 Androgen-dependent apoptosis in male germ cells is regulated through the proto-oncoprotein Cbl

07-01-01 Pleiotropic effects of FGFR1 on cell proliferation, survival, and migration in a 3D mammary epithelial cell model

07-01-01 Control of lateral migration and germ cell elimination by the Drosophila melanogaster lipid phosphate phosphatases Wunen and Wunen 2

07-01-01 Dissecting independent channel and scaffolding roles of the Drosophila transient receptor potential channel

07-01-01 Evolution of skeletal type e–c coupling : a novel means of controlling calcium delivery

07-01-01 Specific integrin and chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms

07-01-01 Cytoplasmic dynein nomenclature

07-01-01 Spying on IgE receptor signaling : simply complex, or not

07-01-01 How does the TOM complex mediate insertion of precursor proteins into the mitochondrial outer membrane

07-01-01 Complete maturation of the plastid protein translocation channel requires a type I signal peptidase

07-01-01 Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis

07-01-01 Ablation of 1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation


		第12期

07-01-01 Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells

07-01-01 Ubiquitin/SUMO modification of PCNA promotes replication fork progression in Xenopus laevis egg extracts

07-01-01 The mobile nucleoporin Nup2p and chromatin-bound Prp20p function in endogenous NPC-mediated transcriptional control

07-01-01 Yeast phosphatidylinositol 4-kinase, Pik1, has essential roles at the Golgi and in the nucleus

07-01-01 Transition from hemifusion to pore opening is rate limiting for vacuole membrane fusion

07-01-01 Influences on neural lineage and mode of division in the zebrafish retina in vivo

07-01-01 Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

07-01-01 Raf-1 sets the threshold of Fas sensitivity by modulating Rok- signaling

07-01-01 Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial–mesenchymal transition

07-01-01 Mutational analyses reveal a novel function of the nucleotide-binding domain of -tubulin in the regulation of basal body biogenesis

07-01-01 Desmoplakin assembly dynamics in four dimensions : multiple phases differentially regulated by intermediate filaments and actin

07-01-01 Terminating Wnt signals : a novel nuclear export mechanism targets activated -catenin

07-01-01 Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11

07-01-01 A novel role for the CBF3 kinetochore–scaffold complex in regulating septin dynamics and cytokinesis

07-01-01 The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin